Tuesday, June 5, 2012

Census reveals unexpected variety of genes involved in cellular transport

Monday, June 4, 2012

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have conducted the first comprehensive census of human cells' export workers. In a study published online today in Nature Cell Biology, they found an unexpected variety of genes involved in transporting molecules to the cell membrane and beyond.

Using a combination of genetics and sophisticated microscopy, Rainer Pepperkok and colleagues systematically silenced each of our 22 000 genes, and observed to what extent this affected the cell's ability to transport a protein. They found that 15% of human genes somehow influence this transport network ? known as the secretory pathway ? including genes that provide a link to other events in and around the cell. Their findings suggest, for instance, that our cells evolved a complex strategy for adapting to changes in their environment. When a cell senses a growth factor called EGF in its surroundings, a protein on the cell membrane aptly named the EGF receptor is taken from the membrane into the cell, starting a chain reaction that ultimately leads the cell to divide, and during which the EGF receptor is degraded. The EMBL scientists have now found that the process also triggers an increase in activity at the early steps of the secretory pathway to transport newly synthesised EGF receptor back to the membrane, where it will be needed again.

Next, the scientists would like to tease out how mechanisms like sensing the environment, controlling genes and transmitting signals are connected to transporting molecules to the membrane, in an effort to better understand how cells work as whole.

###

European Molecular Biology Laboratory: http://www.embl.org

Thanks to European Molecular Biology Laboratory for this article.

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Craig Holman: Wisconsin Recall Election: Disaster Looms for GOP

The latest Marquette University Law School poll shows Wisconsin Gov. Scott Walker seven points ahead of his Democratic challenger Tom Barrett among likely voters in Tuesday's recall election, prompting Walker and the state Republican Party to exuberate confidence of surviving the recall. Even the Republican National Committee is proclaiming that a Walker win has national repercussions as "lights out for Obama," suggesting that this critical swing state has turned red.

Political spin at its finest -- fully void of an actual examination of the facts. Let's take a closer look at what is bubbling underneath the Walker recall election.

First, the gubernatorial recall election is still far too close to call. Walker's campaign will spend about $30 million over the course of the recall election, compared to about $3.1 million by Barrett. These figures do not include the "independent" spending by outside groups -- estimated at about $21 million total -- with most of it coming from pro-Walker groups like the Club for Growth and the Republican Governors Association. By all accounts, Walker should be burying Barrett. But that is not the case, and for good reason. About three-fifths of Walker's campaign war chest has come from out-of-state. The bulk has come from just a few very large donations in excess of the $10,000 contribution limit from wealthy CEOs, such as $500,000 from Houston's Swift Boat founder Bob Perry, $250,000 from Las Vegas casino magnate Sheldon Anderson and the same from Amway founder Richard DeVos of Florida.

Meanwhile, about 80 percent of Barrett's contributions have come from folks in Wisconsin, those who will be voting in the Wisconsin election. Due to a quirk in the state's campaign finance law, Barrett may accept only contributions within the $10,000 limit. (Walker could accept unlimited amounts from the time the recall petitions were taken out until the recall election was called -- a period that ran 4.5 months from Nov. 15 to March 30.)

More importantly, Walker already has spent the bulk of his campaign money. In the final days of the campaign, Barrett has just about the same amount of campaign funds ($1.5 million) to spend as Walker. Walker could not swamp Barrett by outspending him 10-to-1. It will be interesting to see what happens when the spending is relatively equal.

Second, the gubernatorial election is not the only race on the ballot on Tuesday. Four state Republican senators also are being challenged. The Wisconsin state senate is divided 16-16 between Republicans and Democrats. Republicans need lose only one of those senate seats and they lose control of the state senate -- a very likely prospect.

Third, while all this electioneering is going on, everyone seems to be overlooking that Walker may be the subject of a criminal probe. Whatever the outcome of the election, the prospect of scandal tainting the Republican leader and the state GOP in general, is right around the corner. Walker is smack dab in the middle of a John Doe investigation that has led to charges against three of his former aides while Walker served as Milwaukee County Executive. Officials are looking closely into an email exchange between Walker and another aide over a 2010 real estate deal. Walker knows the investigation is serious, spending about $160,000 so far on his defense fund.

So, the real landscape of the Wisconsin recall election is that the gubernatorial race is too close to call, despite Walker outspending his opponent 10-to-1; the Wisconsin Republican Party is likely to lose the state senate; and scandal from earlier official conduct and all this money may well cast a pall over the GOP in general. When Tuesday comes to an end, the ramifications for the Republican party in Wisconsin and Washington, D.C., will be far from over.

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London Hotels Family Rooms | Travel and Leisure

London city with its dynamism enthralls its visitors with its exorbitant hotels providing them with the best accommodation and that too with their families and friends. Many hotels in London provide special services for the families to make their stay the most entertaining and exciting. Some of these hotels also have special provision for the care of the kids including games, bike ride and even free ice creams.

London Hotels Family Rooms have extra beds and space for the children including the cots for the babies. The provision of these rooms however depends on the different hotels and the services they are offering. In most of these hotels, the family rooms may be either just one or two, and rest are just two bed rooms but there are considerable number of hotels which particularly cater to the needs of the families.

In these London hotels, there are also several apartment complexes around London Bridge area which allow you to cook for yourselves and entail you to relax in much spacious surroundings.

In these London Hotels Family Rooms, you can also find small bar towards the rear providing you drinks throughout the day.? You can also have special sitting facility for the guests while many also have provision for providing tea and coffee which could be available to them the entire day.?

Many of these London Hotels with their family rooms are scattered around Central London which are in close proximity to the railway station, airport, markets and even major tourist places. You can also look out for the hotels which are providing you with special privileges and deals for the esteemed guests like discount rates or complimentary breakfast or tea or coffee.

It is highly recommended to get the bookings of these London Hotels Family Rooms in advance especially during the peak season to avoid any hassles.

The charge of these rooms varies from hotel to hotel and is very flexible meeting budget needs of everyone. From the five star hotels to the one star and even the smallest hotel or a longue, you can find one or the other family rooms according to your needs and requirements.

The rates of these London Hotels Family Rooms are very flexible. In the peak season, the prices can shoot up but when the season goes down and there is a decrease in the influx of visitors, the rates too go down. ?So if you are planning to visit London, make sure to get the booking in advance and look for any deals they are offering. This is the best way to make the most of the family rooms being offered by the hotels.

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Monday, June 4, 2012

Shadowgun developer announces zombie shooter for iOS called Dead Trigger

Madfinger Games has announced a new zombie title for iOS and Android at E3 called Dead Trigger, which looks absolutely disgusting. Of course by "disgusting", I mean awesome.


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How To Make Money Online ? Top Internet Marketing Training

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Sunday, June 3, 2012

Boost up your business with business finance loan ? U R Not Alone

Article by Garry Hudson

Boost up your business with business finance loan ? Finance

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If a businessman falls short of cash for further investment, business finance loan can render him valuable help. One can finance his business with small business loan also. It is cheap and easy to deal with. Both these loans are available in secured and unsecured form.

Whoever starts a business wants to make profit out of it. But without proper investment no business can be profitable. So it is necessary to capitalise the business from time to time. Generally, business itself provides funds for further investment. However, sometimes one falls short to manage enough money for business investment. In such circumstances sources like business finance loans render valuable help.

There is no restriction on the utilisation of a business finance loan. One can use this loan for starting up a new business or for launching another business along with the present one. It can be used to buy a business plant, machineries, equipment, raw materials etc. To buy space for a new office or to pay off the pending salaries of the employees this loan can be used. Thus, there are a lot of ways in which you can use this loan and increase the profitability of your business.

For borrowers in UK business finance loans are offered in secured and unsecured form. To take the secured one you have to offer collateral. In return you will be provided with low interest rate, small monthly repayment instalments, long loan period and flexible terms. The unsecured one is quickly processed and risk free for the borrowers. It is available to all types of borrowers.

If you are not in a position to incur high financial debt you can finance your business with small business loan. A small business loan is meant for those who want to capitalise their business with borrowed money but do not like to incur heavy debt burden. As indicated by the name, only a small amount of money is borrowed through this loan. So the borrower is not loaded with a heavy debt burden. They need to pay little amount in the form of interest. Repayment instalments also remains relatively smaller. It requires a short time to repay the loan. So, the debt obligation will be over quickly.

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About The Author: The author is a business writer specializing in finance and credit products and has written authoritative articles on the finance industry. He has done his masters in business administration and is currently assisting Adverse-Credit-Business-Loans as a finance specialist.

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Egypt's Mubarak sentenced to life in prison

In this video image taken from Egyptian State Television, 84-year-old former Egyptian president Hosni Mubarak is seen in the defendant's cage as a judge reads the verdict in on charges of complicity in the killing of protesters during last year's uprising that forced him from power, in Cairo, Egypt, Saturday, June 2, 2012. (AP Photo/Egyptian State TV) EGYPT OUT

In this video image taken from Egyptian State Television, 84-year-old former Egyptian president Hosni Mubarak is seen in the defendant's cage as a judge reads the verdict in on charges of complicity in the killing of protesters during last year's uprising that forced him from power, in Cairo, Egypt, Saturday, June 2, 2012. (AP Photo/Egyptian State TV) EGYPT OUT

In this video image taken from Egyptian State Television, 84-year-old former Egyptian president Hosni Mubarak is seen in the defendant's cage as a judge reads the verdict in on charges of complicity in the killing of protesters during last year's uprising that forced him from power, in Cairo, Egypt, Saturday, June 2, 2012. (AP Photo/Egyptian State TV) EGYPT OUT

Egyptian protesters shout slogans and wave a national flag in front of policemen outside the police academy courtroom as the country braces for a verdict in the trial of ousted president Hosni Mubarak in Cairo, Egypt, Saturday, June 2, 2012. The 84-year-old Mubarak, the first Arab leader to be tried by his own people, faces charges of complicity in the killing of some 900 protesters during last year's uprising that forced him from power. If convicted, he could face the death penalty. The picture on the white flag shows one of the victims of the Jan. 25, 2011 Egyptian revolution. (AP Photo/Amr Nabil)

Egyptian protesters shout slogans in front of policemen outside the police academy courtroom as the country braces for a verdict in the trial of ousted president Hosni Mubarak in Cairo, Egypt, Saturday, June 2, 2012. The 84-year-old Mubarak, the first Arab leader to be tried by his own people, faces charges of complicity in the killing of some 900 protesters during last year's uprising that forced him from power. If convicted, he could face the death penalty. (AP Photo/Amr Nabil)

An Egyptian woman shouts slogans and holds a poster of a protester killed during the 2011 uprising in front of policemen outside the police academy courtroom as the country braces for a verdict in the trial of ousted president Hosni Mubarak in Cairo, Egypt, Saturday, June 2, 2012. The 84-year-old Mubarak, the first Arab leader to be tried by his own people, faces charges of complicity in the killing of some 900 protesters during last year's uprising that forced him from power. If convicted, he could face the death penalty. Poster on white flag showing one of the victims of the January 25th revolution . (AP Photo/Amr Nabil)

CAIRO (AP) ? Hosni Mubarak was sentenced to life in prison Saturday for failing to stop the killing of protesters during the uprising that forced him from power last year. The ousted president and his sons were acquitted, however, of corruption charges in a mixed verdict that swiftly provoked a new wave of anger on Egypt's streets.

After the sentencing, the 84-year old Mubarak suffered a "health crisis" while on a helicopter flight to a Cairo prison hospital, according to security officials who spoke on condition of anonymity because they were not authorized to speak to the media. One state media report said it was a heart attack, but that could not immediately be confirmed.

The officials said Mubarak cried in protest and resisted leaving the helicopter that took him to a prison hospital for the first time since he was detained in April 2011. Mubarak stayed at a regular hospital in his favorite Red Sea resort of Sharm el-Sheikh from his arrest until his trial began in on Aug. 3. The officials said he insisted on the helicopter that he be flown to the military hospital on the eastern outskirts of Cairo where he has stayed during the trial.

Earlier, Mubarak sat stone-faced and frowning in the courtroom's metal defendants' cage while judge Ahmed Rifaat read out the conviction and sentence against him, showing no emotion with his eyes concealed by dark sunglasses. His sons Gamal and Alaa looked nervous but also did not react to either the conviction of their father or their own acquittals.

Mubarak was convicted of complicity in the killing of some 900 protesters during the 18-day uprising that forced him to resign in February 2011. He and his two sons were acquitted of corruption charges, along with a a family friend who is on the run.

Rifaat delivered a strongly worded statement before handing down the sentences. He described Mubarak's era as "30 years of darkness" and "a darkened nightmare" that ended only when Egyptians rose up to demand change.

"They peacefully demanded democracy from rulers who held a tight grip on power," the judge said about the Jan.25-Feb. 11 uprising last year.

Angered by the acquittals of the Mubarak sons and six top police officers, lawyers for the victims' families broke out chanting inside the courtroom as soon as Rifaat finished reading the verdict.

"The people want to cleanse the judiciary," they chanted. Some raised banners that read: "God's verdict is execution."

The charges related to killing protesters carried a possible death sentence that the judge chose not to impose, opting instead to send Mubarak to prison for the rest of his life.

Outside the courtroom on the outskirts of the capital, there was jubilation initially when the conviction was announced, with one man falling to his knees and prostrating himself in prayer on the pavement and others dancing, pumping fists in the air and shooting off fireworks.

But that scene soon descended into tensions and scuffles, as thousands of riot police in helmets and shields held the restive, mostly anti-Mubarak crowd back behind a cordon protecting the court.

Later, thousands of protesters gathered in Cairo's Tahrir Square, birthplace of the uprising, and in the Mediterranean city of Alexandria on Egypt's northern coast. They chanted slogans denouncing the trial as "theatrical" and against the ruling generals who took over for Mubarak, led by his former defense minister. "Execute them, execute them!" chanted the protesters in Alexandria.

Mubarak and his former Interior Minister Habib el-Adly, who was in charge of the police and other security forces at the time of the uprising, were convicted of failing to act to stop the killings during the opening days of the revolt, when the bulk of protesters died. El-Adly also received a life sentence.

Most of the dead were either shot or run over by police vehicles in Cairo and a string of major cities across the country.

Mubarak and his sons ? one-time heir apparent Gamal and wealthy businessman Alaa ? were acquitted on corruption charges, with the judge citing a 10-year statute of limitations that had lapsed since the alleged crimes were committed.

Just days before the verdict was made public, the state prosecutor leveled new charges of insider trading against the two sons. It now appears that these charges may have been an attempt to head off new public outrage once the acquittals of the Mubarak sons were made public.

It has appeared all along that prosecutions since Mubarak's fall targeting relatively few high level officials and their cronies have been motivated largely by a desire to appease public anger expressed in massive street protests that continued long after Mubarak's ouster.

Scores of policemen charged with killing protesters have either been acquitted or received light sentences, angering relatives of the victims and the pro-democracy youth groups behind the uprising.

Rock-throwing and fist fights outside the courtroom left at least 20 people injured, and a police official said that four people were arrested.

Thousands of riot police and policemen riding horses had cordoned off the building to prevent protesters and relatives of those slain during the uprising from getting too close. Hundreds stood outside, waving Egyptian flags and chanting slogans demanding "retribution." Some spread Mubarak's picture on the asphalt and walked over it.

Mubarak's verdict came just days after presidential elections have been boiled down to a June 16-17 contest between Mubarak's last prime minister, one-time protege Ahmed Shafiq, and Mohammed Morsi of the Muslim Brotherhood, a fundamentalist Islamist group that Mubarak persecuted for most of his years in power.

___

Associated Press writer Maggie Michael contributed to this report.

Associated Press

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